convert

convert(
    IC50_df
    model
    RT=None
    LsT=None
    Kds=None
    y0=None
    compound_sel=False
    ci=True
    verbose=False
)

Function for converting IC50 to Kd using coleska, cheng_prusoff and cheng_prusoff_corr models.

Parameters

Name	Type	Description	Default
IC50_df	DataFrame	Pandas DataFrame containing the fitted IC50 values.	required
model	str	Name of the conversion model. Options: coleska, cheng_prusoff, cheng_prusoff_corr	required
RT	float or int	Total concentration of the receptor.	None
LsT	float or int	Total concentration of the labeled ligand.	None
Kds	float or int	Dissociation constant of the labeled ligand.	None
y0	float or int	Parameter used in the corrected Cheng-Prusoff model.	None
compound_sel	list	List of compounds to execute the function on. If set to False, all compounds will be used.	False
ci	bool	Whether to calculate 95% confidence intervals.	True
verbose	bool	If set to “True”, more detailed output is printed. Intended mainly for troubleshooting.	False

Returns

Name	Type	Description
	DataFrame	Pandas DataFrame containing the conversion results.